Tadalista 60, which contains 60 mg of Tadalafil, should be used with caution and not mixed with certain medications or substances, as they can cause harmful interactions. Ritonavir and other protease inhibitors used to treat HIV/AIDS can significantly increase the blood levels of Tadalafil, increasing the likelihood of side effects. If you are on these medications, you should speak with a healthcare provider about adjusting the dose or considering alternatives.