Mechanism Study of Heavy-oxygen Water in the Synthesis of γ-Lactam

[Mindy]

Heavy-oxygen water is a chemical substance. It is a colorless, odorless and tasteless liquid. Some physical properties are slightly different from those of ordinary water. It is mainly used as a tracer in scientific research fields such as chemistry, biology, medicine, agriculture, and geology.
By designing a multifunctional supported single-atom cobalt catalyst, a four-component reductive coupling reaction of nitroaromatics, aldehydes, acetylenic esters and water was developed, and the direct, diversified and single diastereoselective synthesis of α-hydroxy-γ-lactam compounds was achieved. This catalytic synthesis method has the characteristics of wide substrate and functional group compatibility, simple operation, high atomic and step economy, and excellent catalyst reusability. The mechanism mechanism was studied experimentally using heavy oxygen water.

γ-Lactams are widely present in bioactive natl products, synthetic drugs, agricultl chemicals and functional materials. γ-Lactam compounds have been used as β-lactamase I, plant growth regulator II, and drugs for the treatment of hypertension, pain, nervous system disorders and related diseases. At present, although there are many methods available for the synthesis of γ-lactams, the direct, selective and diversified synthesis of α-hydroxy-γ-lactams using simple and readily available raw materials is an unsolved synthetic problem.